Phytochemical investigation of <i>bauhinia winitii</i> based on alpha-glucosidase inhibitory effect and molecular docking affirmation

Background: Bauhinia winitii (BW) (Fabaceae) plant revealed poor phytochemical investigation and anti-diabetic report. As one of the family which known with abundant flavonoids content, contrary, BW was only used for treatment diarrhea in Thai conservative remedy. Objectives: The aim this study to investigate constituents anti-alpha glucosidase activity BW. Materials Methods: Phytochemical based on alpha-glucosidase inhibitory effect. Isolated compounds were determined by chromatographic spectroscopic techniques. enzymatic test then connected molecular docking affirmation. Results: ethyl acetate ethanol extracts from leaves woods exhibited strongest above 60% inhibition. Six isolated these extracts, naringenin (1), luteolin (2), isoquercitrin (3), griffonilide (4), lithospermoside (5), epi-β amyrin (6). showed that performed potential results as highest IC50 0.41 mM. ensured activated at same binding enzyme active site. Conclusion: This would be first report chemical its presented inhibitors.